Can thrust reversers be activated during flight?

Thrust reversers are designed for use primarily during landing to provide additional deceleration and are not intended to be deployed in flight under normal operations. Activating thrust reversers while airborne can lead to a loss of control and potentially compromise the safety of the aircraft. The system is engineered to operate only on the ground during landing roll or rejected takeoff procedures. Therefore, deployment in flight is explicitly prohibited to ensure the aircraft maintains its aerodynamic stability and performance. This is a critical limitation that pilots must adhere to for safe operation.